Relationship Between the Single Nucleotide Polymorphism rs11558471 in the SLC30A8/ZnT8 Gene and Cardiometabolic Markers in Postmenopausal Women.

Postmenopausal women have more risk factors for metabolic syndrome, and genetic alterations in SLC30A8 (zinc transporter 8 [ZnT8]) are directly related to these factors. Our aim was to assess the relationship of the single nucleotide polymorphism (SNP) rs11558471 in the SLC30A8/ZnT8 gene with cardiometabolic markers in postmenopausal women. This cross-sectional study included 53 postmenopausal women divided into two groups according to the SNP genotype (AG + GG [n = 25] and AA [n = 28]). Anthropometric, dietary, and biochemical (glycemic, lipidic, hepatic, renal, and hormonal markers) variables were evaluated and compared between groups. No differences in glycemic, hepatic, renal, and hormonal markers were found between groups. However, the group with the polymorphic allele (AG + GG) had a better lipid profile than non-carriers (total cholesterol, p = 0.041; low-density lipoprotein cholesterol [LDL-c], p = 0.035; non-high-density lipoprotein cholesterol [non-HDL-c], p = 0.043). Logistic regression showed that the group with polymorphic allele had lower chances of increasing levels of LDL-c (odds ratio [OR] = 0.225, p = 0.012) and non-HDL-c (OR = 0.316, p = 0.045). After adjusting for age, body mass index, physical activity, and use of diabetes and dyslipidemia drugs, only LDL-c remained associated (OR = 0.218; p = 0.017). The variant allele of SNP rs11558471 in the SLC30A8 gene was associated with better LDL-c levels, which helps reduce the risks for cardiovascular diseases in postmenopausal women.

Fatores associados ao risco de insegurança alimentar e nutricional em famílias de assentamentos rurais / Factors associated with food insecurity risk and nutrition in rural settlements of families

Resumo A insegurança alimentar ocorre quando o direito a uma alimentação em qualidade e quantidade adequada de forma regular é desrespeitado. O objetivo deste estudo foi identificar a situação de insegurança alimentar (IAN) e suas possíveis associações com variáveis socioeconômicas e dietéticas em assentamentos rurais de Sergipe. Essa situação foi verificada através da escala brasileira de insegurança alimentar e as associações através da análise de regressão multivariada por odds ratio (OR). Foram avaliadas 179 famílias de quatro assentamentos do estado de Sergipe. Identificou-se prevalência de 88,8% de IAN, sendo 48,6% insegurança leve, 25,1% moderada e 15,1% grave. Associação estatística ajustada foi encontrada entre a IAN e as variáveis renda familiar per capita (ORa = 3,11, p = 0,008) e variedade alimentar (Ora = 2,73, p = 0,004). As famílias apresentaram alta prevalência de insegurança alimentar e nutricional, determinada nesta população, pela baixa renda familiar e pela baixa variedade da alimentação. É imprescindível políticas públicas mais efetivas, que, de fato, garantam a segurança alimentar e sejam mais completas, visando também à educação nutricional e maior possibilidade para produção de alimentos.

Abstract Food insecurity occurs when the right to food in adequate quality and quantity on a regular basis is disrespected. This study aimed to identify food and nutrition insecurity (FNI) and its possible association with socioeconomic and dietary variables in rural settlements of Sergipe. We verified food insecurity through the Brazilian of Food Insecurity Scale and associations via odds ratio multivariate regression analysis. We evaluated 179 families from four rural settlements in the state of Sergipe. An FNI prevalence of 88.8% was identified (48.6% light insecurity, 25.1% moderate and 15.1% severe). An adjusted statistical association was found between FNI and variables family income per capita (ORa = 3.11, p = 0.008) and food variety (ORa = 2.73, p = 0.004). Families showed high prevalence of food and nutritional insecurity, determined by low income and low variety of food in this population. It is essential to implement more effective and comprehensive public policies that actually ensure food security, also aiming at nutrition education and greater food production opportunities.